Patients with bile reflux do not need to take long-term medication, and the medication can be stopped when the symptoms improve, but it should be controlled by diet. Bile reflux will lead to gastric mucous membrane damage, manifested as symptoms of stomach pain and bloating, which can be treated by controlling risk factors, inhibiting gastric acid to protect the gastric lining, and can be treated surgically in severe cases. For patients with mild to moderate symptoms, medication can be discontinued when symptoms improve, but attention should be paid to quit smoking and drinking, avoid excessive satiety, and eat appropriate foods containing fiber, some patients can keep their condition stable. For patients with more obvious symptoms, they need oral treatment with drugs that inhibit gastric acid and protect the mucosa, such as omeprazole, and those with obvious gastric distension need oral treatment with drugs that promote gastric motility, such as Itopride. A few patients need surgical treatment to inhibit bile reflux in the pyloric region. Patients with bile reflux should assess the severity of the condition under the guidance of a physician and be treated in an appropriate manner, and medications should be taken as prescribed.