If the patient develops persistent chest pain that gets progressively worse after a sudden stabbing pain in the heart, it is important to consider high-risk chest pain, such as aortic coarctation, pulmonary embolism, acute coronary syndrome, and tension pneumothorax, which are all conditions in which the heart has the clinical symptom of a sudden stabbing pain and persistent pain that is not relieved. Several of these conditions have low morbidity but high mortality rates and must be treated with aggressive hospitalization when present. For mild and dangerous chest pain, which will be transformed into dull and boring pain after sudden stabbing pain in the heart and will gradually worsen with breathing, it should be considered that the patient has coronary artery disease or angina pectoris, acute myocarditis, acute pericarditis, or extensive pulmonary infection or pleurisy, when the persistent pain mentioned above will occur, and the gradually worsening of the symptom will occur with breathing. In addition, if the patient develops a disease of the chest wall, often in intercostal neuralgia or herpes zoster pain, there will be a sudden stabbing sensation, which is gradually relieved, and then there will be a sudden stabbing clinical manifestation.