The significance of early gastric cancer screening The status quo of gastric cancer in China is high incidence rate, low early diagnosis rate and high mortality rate. The prognosis of gastric cancer is closely related to the timing of diagnosis. The 5-year survival rate of early gastric cancer patients, regardless of whether there is lymph node metastasis or not, exceeds 90% after surgery, and the 10-year survival rate of small gastric cancer and micro gastric cancer in the initial stage can reach 100%. However, the 5-year survival rate of middle and late stage gastric cancer is still less than 30%, and the treatment effect is poor and the cost is high, which brings heavy economic and psychological burden to patients’ families and society. At present, the diagnosis and treatment rate of early gastric cancer in China is less than 10%, which is much lower than 70% in Japan and 50% in Korea. Therefore, early, timely and accurate detection of gastric cancer is of great significance to reduce the mortality rate of gastric cancer. Alarm symptoms of early gastric cancer Sudden appearance of indigestion symptoms such as unexplained upper abdominal discomfort, weakness, wasting, etc., and they are more persistent and fast progressing; the prominent manifestations are rapid decrease of appetite, abdominal fullness after eating, more than 5 years, with indigestion, wasting, anemia and gastric bleeding. Screening targets of early gastric cancer According to the national conditions and epidemiology of gastric cancer in China, those who meet any of the following items 1 and 2-6 should be classified as high-risk group of gastric cancer and recommended as screening targets: age above 40 years old, male or female; people in areas with high incidence of gastric cancer; people with H.pylori infection; people with chronic atrophic gastritis, gastric ulcer, gastric polyps, post-surgical residual stomach, hypertrophic gastritis, pernicious anemia, etc. Pre-cancerous diseases such as gastric cancer; first-degree relatives of gastric cancer patients; presence of other high-risk factors for gastric cancer (high salt, pickled diet, smoking, heavy alcohol consumption, etc.). Screening methods for early gastric cancer The occurrence of gastric cancer is a long and gradual process, which provides the possibility of screening and intervention for people with high risk of gastric cancer. Currently, serological primary screening combined with endoscopy is commonly used as a way to detect early gastric cancer. The subject draws 2ml of venous blood and performs serum gastric function test to detect the risk of gastric mucosal lesions in time. For patients with abnormal serum gastric function test, further fine gastroscopy and pathological examination can greatly improve the detection rate of early gastric cancer. Therefore, for those who have the above alarm symptoms or are at high risk, serological tests should be performed once a year, and if abnormalities are found, fine gastroscopy should be performed, so that early detection of gastric cancer and early treatment can greatly improve the survival rate and quality of life of patients.