Toe skin hardening cracking may be scaly keratosis pilaris, eczema, exfoliative keratolysis and other causes, can be externally applied ointment treatment, oral medication. 1. scaly keratosis pilaris: it is caused by dermatophyte infection, manifested as foot skin roughness, thickening, desquamation, dryness, cracking, etc., you can use clotrimazole, miconazole and other topical, if necessary, can be combined with oral itraconazole and other drugs. 2. Eczema: it is an inflammatory disease that involves the superficial dermis and the epidermis, and it occurs in the exposed parts of the feet, forearms and calves, which can lead to hardening and cracking of the skin of the toes, and it can be treated with glucocorticoid ointment, such as mometasone furoate, which has anti-inflammatory effects. 3. Exfoliative keratolysis: commonly known as peeling of the hands and feet, severe cases can have cracked fingers, pain and other symptoms, you can use retinoic acid cream, salicylic acid ointment, urea cream or use mild emollients such as petroleum jelly ointment. Oral vitamin combinations may also improve the symptoms of exfoliative keratolysis. Toe skin hardening cracking may also have other causes, it is recommended to go to the hospital in a timely manner, improve the examination to clarify the cause of the disease, to give targeted treatment or treatment, under the guidance of the doctor, follow the doctor’s instructions and medication.