In the middle of the night heartbeat tingling limbs, may be physiological factors, after regulating emotions can be relieved; may also be fast-type arrhythmia, myocardial ischemia, hyperthyroidism and other diseases. 1. Physiological factors: such as too much emotional excitement, nervousness, fear, or sleep body long time pressure limbs. Generally, by adjusting the emotion and changing the sleeping posture, it can be gradually relieved. 2. Disease factors: (1) Tachyarrhythmia: choose appropriate drugs according to the type of arrhythmia, such as atrial fibrillation, use amiodarone and other drugs to control the heart rhythm as prescribed by the doctor; such as frequent premature beats with obvious symptoms, use metoprolol and other drugs. If drug treatment is ineffective, electric cardioversion or radiofrequency ablation can be chosen. Pay attention to the side effects such as bradycardia and dizziness. (2) Myocardial ischemia: mostly caused by atherosclerosis, coronary artery spasm, coronary artery embolism, etc., should follow the doctor’s instructions to use drugs to expand the coronary artery, reduce the load on the heart, and prevent myocardial infarction, such as nitroglycerin, aspirin and atorvastatin. Pay attention to side effects such as headache, bleeding and myalgia. If the coronary artery is severely narrowed or occluded, stent implantation or coronary artery bypass grafting may be considered. (3) Hyperthyroidism: Use propylthiouracil, iodine, propranolol and other drugs to inhibit the synthesis and release of thyroid hormones and control the clinical symptoms of hyperthyroidism. Pay attention to the side effects such as arthralgia and bradycardia. There are many other causes of rapid heartbeat and numbness of limbs in the middle of the night, such as hypokalemia, cerebral hemorrhage, cerebral infarction, etc. It is recommended to consult a doctor in a timely manner to investigate the cause of the disease and actively treat it, so as not to delay the condition.