Hard pimples on the face usually belong to cystic nodular acne, which can be eliminated by medication or physical therapy, but may recur. 1. Medication: Patients can use topical antibiotics, such as fusidic acid ointment, mupirocin ointment, etc. At the same time, patients can also take oral retinoids such as isotretinoin. At the same time, patients can also take oral retinoids such as isotretinoin soft capsules, antibiotics such as doxycycline tablets and other drugs. 2. Physical therapy: If patients feel that the drug treatment is slow, they can go to the regular hospital for carbon dioxide fractional laser to carry out the treatment, only opening and not squeezing, directly destroying the anaerobic environment for the growth of Propionibacterium acnes. For patients with hard acne on the face, it is recommended to go to a regular hospital for examination and standardized treatment under the guidance of a professional doctor. Drugs need to be used in accordance with medical advice.