LDL 4.6mmol/L exceeds the normal reference value, which is more serious and needs to be controlled by improving lifestyle or taking medication. The level of LDL is closely related to the development of atherosclerosis, which is an important causative factor of coronary heart disease, cerebral infarction and other cardiovascular diseases. Therefore, LDL level should be strictly controlled, and for patients who have been diagnosed with coronary heart disease, diabetes mellitus and other diseases, it should not only be lower than the reference value, but also be controlled to 1.8mmol/L or even lower. Therefore, for LDL 4.6mmol/L is more serious. For this situation can be taken to improve the lifestyle approach, usually pay attention to avoid greasy diet, increase physical exercise, quit smoking and drinking, maintain sufficient rest. If necessary, medication can be taken, statins such as Rosuvastatin, cholesterol absorption inhibitors such as ezetimibe, bile acid sequestering agent such as kolestenamide, PCSK9 inhibitor iloyuzumab and other drugs. It is recommended to consult a doctor in time for standardized diagnosis and treatment.