In the case of osteonecrosis of the jaw caused by the use of zoledronic acid drugs, in the early stages there are often no specific symptoms, and the main manifestation is mild oral pain, especially in the area underneath the dental bed of the jaw. As it progresses, the pain worsens, which in turn leads to localized facial numbness, localized swelling of the gums, showing very obvious periodontitis changes, followed by loosening of the teeth. As the condition worsens, the loose teeth are usually extracted because it is difficult for the doctor to accurately determine that it is necrosis of the jawbone. Once the patient’s teeth are removed, the alveolar bone is exposed and the entire bone of the mandibular region is exposed, and this is often accompanied by recurrent infections in the mouth, a very bad odor in the mouth, and even fistulas, which can seriously affect the quality of life. What is very serious is that there is generally no particularly effective treatment for osteonecrosis of the jaw, so osteonecrosis of the jaw is the most serious complication of zoledronic acid.