Fenestrated vascular network formation in the lower esophagus suggests the presence of Barrett’s esophagus. Barrett’s esophagus is a pathology in which the squamous epithelium of the lower esophagus is replaced by columnar epithelium, with or without intestinal epithelial hyperplasia. Endoscopically, it can be manifested as fenestrated blood vessels at the junction of the stomach and the dentate line, a tongue or island shape of the dentate line, mucosal hyperplasia of the cardia glands in the lower part of the esophagus, and mucosal hyperplasia of the fundic glands in the lower part of the esophagus, which is usually regarded as a pre-cancerous lesion. In addition, patients should maintain a light diet in daily life, avoid spicy, overly acidic and other stimulating foods, do not lie down immediately after eating, and be on time for regular checkups. If a patient develops Barrett’s esophagus, it is recommended to go to the hospital in time for targeted treatment under the doctor’s guidance to minimize the adverse effects of the disease.