Usually, bisphosphonates can be used as an adjunctive treatment for bone metastases, but not directly to treat bone metastases. Bone metastasis is caused by the spread of tumor in patients with intermediate or advanced cancer. Bisphosphonates can be used for bone pain and hypercalcemia caused by bone metastasis, which can mainly inhibit the destruction of local bone caused by bone metastasis and reduce the pain of patients, but it does not have the effect of controlling tumor metastasis and recurrence. In order to treat bone metastasis, in addition to the use of bisphosphonates, it is also necessary to combine with radiotherapy, chemotherapy, stem cell transplantation therapy, immunotherapy, targeted drug therapy, etc., so as to achieve the purpose of inhibiting the growth, development and spread of the tumor.