Pancreatic cancer is known as the “king of cancer” because of its insidious onset, rapid progress, high mortality rate and poor treatment effect. Statistics show that the one-year survival rate of patients diagnosed with pancreatic cancer is only 20% and the five-year survival rate is only 6%. In pancreatic cancer treatment, the most important factor leading to high mortality rate is also the postoperative complications. In China, 50%-70% of pancreatic cancer surgeries do not meet the requirement of radical cure, so much so that the recurrence rate within one year is very high and there are many complications. “With the development of minimally invasive techniques, especially laparoscopic techniques, there are greater advantages and great progress in the treatment of pancreatic diseases. Laparoscopic pancreatic surgery has been applied to tumors, inflammation, trauma, congenital malformations, etc.” Pancreatic surgery is called “difficult, complicated and heavy”, and it is the fourth and most difficult level in the general surgery classification, with many complicated surgical steps. Therefore, the application of minimally invasive techniques is relatively cautious, but in recent years, the development of laparoscopic technology and the application of robotic systems have made a qualitative leap in the development of minimally invasive pancreatic surgery. Laparoscopic pancreaticoduodenectomy is recognized as the most difficult and challenging minimally invasive laparoscopic surgery, which requires the surgeon to be highly skilled in open surgery and laparoscopic techniques. This procedure is now gradually being performed in our department. In addition, there have been great developments in the treatment of locally advanced pancreatic cancer. Locally advanced pancreatic cancer is defined when the celiac artery or superior mesenteric artery or both are surrounded by the tumor in 30%-35% of the diagnosis. If radiotherapy or chemotherapy is administered, its efficacy is limited, and physical ablation therapy has some effect. Due to the special organ of the pancreas, any type of ablation is bound to have a high complication rate and mortality. In recent years, the maturity of “NanoKnife” technology has brought a boon to such patients. In 2005, Davalos first demonstrated the effectiveness of IRE technology as an ablation method. The effectiveness of the IRE technique as an ablation modality was first demonstrated by Davalos in 2005. The IRE technique has been shown to ablate tumor tissue without damage to blood vessels, and its treatment can significantly reduce pain in patients with advanced pancreatic cancer and significantly decrease the amount of pain medication. For patients with locally advanced pancreatic cancer diagnosed by intraoperative exploration, it can also be combined with intraoperative radiotherapy in order to minimize tumor load and enhance the effect of chemotherapy. The above two techniques are already under preparation in our department and are expected to be carried out this year. Although minimally invasive treatment has been more effective in pancreatic diseases, the international medical level can now increase the survival rate of other types of cancer by 10 percentage points for every 10 years of development, while pancreatic cancer is only 2 percentage points. Therefore, Professor Rufus Chen reminds the public that it is more meaningful to maintain healthy living and eating habits and to do a good job in early detection and treatment of pancreatic cancer.