The effect of pregnancy on hepatitis: pregnant women’s livers are in a relatively ischemic condition during pregnancy, the burden of endogenous estrogen production increases significantly during pregnancy, and estrogen must be inactivated in the liver, which undoubtedly also aggravates the burden on the liver. Fatigue, hemorrhage, surgery, anesthesia, and upstream infections that tend to occur when the birth canal is open during labor and delivery can exacerbate liver damage. If acute hepatitis and post-hepatitis cirrhosis occurring in late pregnancy, under the influence of the above factors, heavy hepatitis is prone to occur, seriously affecting the lives of mother and child. Therefore, throughout the pregnancy, the liver function of pregnant women must be tested, and once abnormalities are detected, specialists should be consulted to deal with them. Effects of hepatitis B on pregnancy: If hepatitis activity occurs during pregnancy, adverse outcomes such as early miscarriage, preterm labor, stillbirth, and neonatal asphyxia may occur, and are more likely to occur in late pregnancy. It is currently believed that the hepatitis B virus itself does not cause teratogenesis or congenital disorders. The main effect of hepatitis B virus on pregnancy is still mother-to-child transmission. Because pregnancy itself increases the burden on the liver, and hepatitis activity may interrupt or fail a pregnancy, it is important that women with hepatitis B who decide to become pregnant undergo preconception counseling to test for markers of the hepatitis B virus and liver function to assess whether the liver is able to carry the burden of pregnancy. In general, pregnancy is not advocated in patients with acute hepatitis B or in patients with decompensated cirrhosis. Risk of mother-to-child transmission of hepatitis B: Hepatitis B virus can be transmitted to the next generation through the placenta, labor and delivery, and through close contact, and the vast majority of hepatitis B infections acquired during infancy will be difficult to recover from throughout life. It is possible to interrupt mother-to-child transmission by taking relevant preventive measures during pregnancy and after delivery. The comprehensive interruption measures of safe and hygienic lifestyle during pregnancy, antiviral treatment, injection of high potency hepatitis B immunoglobulin within 24 hours after delivery and vaccination against hepatitis B can achieve an interruption rate of about 95%, while pregnant women with hepatitis B who do not have any interruption measures will have a possible transmission rate of 90%.