The main parts of the upper abdomen right in the middle of the stomach are the stomach, pancreas, liver, etc. Therefore, the hidden pain in the middle of the upper abdomen of the stomach with pressure pain may be mainly related to the occurrence of diseases in the stomach, pancreas, liver and other parts of the stomach. As the pain site may be offset, therefore, when the gallbladder disease, may also cause pain in the middle of the upper abdomen of the stomach. 1, stomach disease: such as gastritis, gastric ulcer, gastric bleeding, etc., when gastritis and gastric ulcer occur, suggesting that the gastric mucosa has been inflammation, at this time will produce pain, at this time, if you press the middle of the upper abdomen of the stomach, will make the gastric mucosa and food contact, food on the gastric mucosa to produce stimulation At this time, if pressure is applied to the middle of the upper abdomen, the stomach mucosa will come into contact with food and the food will stimulate the stomach mucosa, resulting in painful pressure. If there is gastric bleeding combined with other gastric diseases, it may also cause hidden pain in the stomach, which usually requires medication for causal treatment as prescribed by the doctor. If it is bacterial gastritis, you need to use antibiotic drugs such as gentamicin and norfloxacin for treatment as prescribed by the doctor; 2. Pancreatic diseases: as the pancreas is in the upper abdomen of the body, when suffering from pancreatic diseases, there may also be hidden pain and pressure pain in the middle of the upper abdomen of the stomach, for example, when the patient suffers from pancreatitis and other diseases, in addition to hidden pain and pressure pain, there may also be persistent pain in the upper abdomen, and the pain is radial distribution. If it is acute pancreatitis, you need to take drugs such as omeprazole and other drugs to inhibit gastric acid secretion under the guidance of a doctor, and you can also take analgesic and antispasmodic drugs such as pethidine and antibiotics such as cephalosporin for treatment, and in serious cases, you need to undergo pancreatic duct decompression and pancreatic resection for treatment; 3. Liver diseases: some patients may suffer from liver diseases such as hepatitis and cirrhosis, which may also cause hidden pain in the middle of the upper abdomen and pressure pain, and patients may also have symptoms such as weakness, loss of appetite, and spider nevus. If patients are diagnosed with hepatitis, they need to take liver-protective drugs such as glycopyrrolate preparations under the guidance of a doctor, and they can also take anti-fibrotic drugs such as Anluo Fibro Pills for treatment; 4. Gallbladder disease: the gallbladder is located in the right upper abdomen of the body, but when gallbladder disease occurs, such as cholecystitis and gallbladder perforation, its pain location will shift somewhat and produce pain in the middle of the upper abdomen of the stomach. Patients with cholecystitis need to take cholestatic drugs, such as cholestatic tablets, deoxycholic acid tablets, and can also take antibiotic drugs such as metronidazole for active treatment to avoid gallbladder perforation and other serious symptoms caused by cholecystitis; 5. Colon disease: transverse colon starts from the right curvature of the colon and is located in the upper abdomen. If the patient has transverse colon spasm, the patient may experience hidden pain or pressure pain in the middle of the upper abdomen. At this time, you can follow medical advice to use some antispasmodic drugs for treatment, such as belladonna tablets, etc. You should also avoid eating cold, spicy and stimulating foods in your daily diet, and the discomfort of the transverse colon will be gradually relieved. When patients have hidden pain and pressure pain in the middle of the upper abdomen, they should go to the hospital for examination in time, they can do abdominal ultrasound, CT, gastroscopy, enteroscopy, etc., and combine with clinical physical examination to clarify the specific causes of the disease and carry out targeted treatment.