Joint pain in the ankle due to rheumatism may be related to uncontrolled rheumatic diseases, which are commonly treated clinically with drugs such as non-steroidal anti-inflammatory drugs or glucocorticoids. Rheumatism is a group of chronic diseases, may be associated with infection, genetics, immunity, etc., often involving bone and joints and their surrounding tendons, synovium, cartilage, ligaments and other soft tissues, and the heart, kidneys and other organs. Joint pain caused by rheumatism is often applied to non-steroidal anti-inflammatory drugs, glucocorticoids and other drugs. Non-steroidal anti-inflammatory drugs such as celecoxib are commonly used to inhibit the cyclo-oxygenase pathway to achieve the effect of pain, glucocorticoids are commonly used in prednisone, methylprednisolone, etc., which has a strong anti-inflammatory and immune-suppressing effect, and has a strong anti-pain effect. The etiology and mechanism of rheumatism are complex, and the causes of most diseases are still unclear. Rheumatism patients are advised to go to the rheumatology and immunology department of regular hospitals in a timely manner, and follow the doctor’s instructions for standardized diagnosis and treatment. Drugs should be used in accordance with medical advice, do not self-medication.