Intermetatarsal nerve sheath tumor belongs to benign tumors, originated from nerve sheath and grows slowly. Its treatment is mainly based on the size, location and severity of the tumor, and general treatment, physiotherapy, drug treatment and surgery are given according to the condition in clinic. 1. General treatment: for small size of intermetatarsal nerve sheath tumor and insignificant symptoms, it is recommended to pay attention to rest, reduce the activities of the affected side of the foot, especially strenuous exercise, and follow up regularly. 2. Physiotherapy: If surgical treatment is adopted, after scraping the lesion, physiotherapy can be carried out on the tumor bed, such as electric knife cauterization, liquid nitrogen freezing and so on. 3. Medication: For those with severe pain, pain-relieving drugs such as ibuprofen can be taken to treat the symptoms. If surgical treatment is given, antibacterial drugs such as penicillin and levofloxacin need to be given after surgery to prevent infection. 4. Surgery: Conservative treatment is often ineffective, so the disease is mainly treated by surgery, the main way is to excise the tumor lesion, if necessary, combined with local radiation therapy to prevent recurrence. Suffering from intermetatarsal nerve sheath tumor, it is recommended to go to the hospital for consultation and examination, to clarify the condition, to be treated by professional physicians, and to use the drugs under the guidance of professional physicians.