Soreness and swelling of calves at night can be caused by osteoporosis, lumbar spine disease, vascular disease and so on, which can be treated by general therapy, physical therapy, medicine and surgery. 1. Osteoporosis: Hypocalcemia caused by osteoporosis can make calf soreness and discomfort, which is mainly caused by the lowering of blood calcium, the elevation of nerve excitability and the continuous contraction of calf muscles. Calcium carbonate and calcium gluconate can be taken orally under the guidance of the doctor to supplement calcium treatment. 2. Lumbar spine disease: Lumbar disc herniation and other diseases can lead to the pressure on the nerves that innervate the calf, resulting in soreness, numbness and other symptoms of discomfort in the calf. It can be prescribed oral ibuprofen and other anti-inflammatory and analgesic drugs and methylcobalamin and other nutritive nerve medications, but also hot compresses, traction, massage therapy, and when the condition is serious, surgical treatment. 3. Vascular diseases: Ischemia of the lower limb arteries, lower limb arterial stenosis and other diseases can cause muscle ischemia, and cold stimulation can lead to soreness and swelling of the calves at night when sleeping. Under the guidance of the doctor can apply aspirin and other antiplatelet drugs, pay attention to strict smoking cessation, develop healthy habits, pay attention to the lower limbs to keep warm and so on. When the calves are sore and swollen at night, it is necessary to consult a doctor in a timely manner, under the treatment of a specialist to actively perform appropriate treatment, which will help improve the symptoms of calf soreness and swelling as soon as possible.