a1 acid glycoprotein, should be α1-acid glycoprotein, 143mg/L, lower more, should be taken seriously. Normal reference value is 500~1500mg/L, 143mg/L belongs to the low state, the patient may suffer from malnutrition, liver dysfunction, nephrotic syndrome and other diseases. Specific causes need to be confirmed after examination by a doctor. 1. Malnutrition: It is manifested by reduced subcutaneous fat content and weight loss. Edematous children appear to be fat, edematous with reduced skin elasticity, long duration of illness and short height. 2. Liver dysfunction: symptoms such as hepatic ascites, splenomegaly, fatigue, diarrhea, hepatitis and liver damage, mostly intermittent, daily fatigue and mental stress will also be accompanied by hypersplenism, cirrhosis and other diseases. 3. Nephrotic syndrome: increased permeability of glomerular basement membrane, massive proteinuria, nephritis, hyperlipidemia, edema, with persistent microscopic hematuria, persistent hypertension, azotemia and hypocomplementemia. If you find that α1-acid glycoprotein is low, you should consult a doctor in time, and standardize the treatment according to the doctor’s prescription after making a clear diagnosis.