Taking painkillers generally does not affect the H. pylori test, the main drugs that affect the test results are antibiotics such as cephalosporin and proton pump inhibitors such as omeprazole, etc. It is recommended that you consult with your doctor strictly before taking the test to ensure that the test results are accurate. The H. pylori test is mainly used for the detection and diagnosis of common diseases such as chronic gastritis, peptic ulcer, gastric mucosa-related lymphoid tissue lymphoma and gastric cancer. Precautions for H. pylori test, including four weeks before the test should not take any bismuth, antibiotic drugs, such as bismuth potassium citrate, cephalosporin, levofloxacin, amoxicillin, etc., and two weeks before the test should not take the proton pump inhibitors, such as omeprazole or pantoprazole, etc., which will easily lead to inaccurate test results, affecting the doctor’s correct diagnosis of the disease. Therefore, taking painkillers is relatively less influential. It is recommended to maintain a light diet and prepare strictly according to the precautions instructed by the doctor before doing the H. pylori test, so as to avoid adverse factors affecting the test results.