The difference between alcohol and povidone iodine lies in the different ingredients, application range, and irritation. 1. Different components: alcohol contains ethanol and other components, while povidone iodine contains polyvinylpyrrolidone and iodine monomer and other components. 2. Scope of application: Alcohol is mainly used for the disinfection of medical machinery and instruments, and can play the role of disinfection. Iodophor belongs to organic compound, mainly used for skin surface disinfection, can inhibit the growth of bacteria. 3. Irritation: If alcohol is applied to the wound, it may irritate the local skin and affect the recovery of the wound. When iodophor is applied to the wound, it is less irritating to the wound and can promote wound healing to a certain extent. When using povidone-iodine or alcohol in daily life, the choice should be made under the guidance of a doctor and in conjunction with one’s own situation.