The pain in the middle of the palm may be caused by physiological reasons such as long-term strain injury, or it may be caused by pathological reasons such as bacterial invasion, trauma and nerve compression. 1. Physiological reasons: the palm and wrist are attached to rich muscles, tendons and other soft tissues, long-term high-intensity activities may lead to fatigue injury of these soft tissues, aseptic inflammation, resulting in lactic acid, leukotriene and other metabolites accumulation, stimulation of the peripheral nerve roots, the emergence of the middle of the hand palm pain symptoms, such as tenosynovitis, carpal tunnel syndrome and other common symptoms. 2. Pathological causes: infection of the intermetacarpal space caused by bacterial invasion may also cause pain in the middle part of the palm; secondly, trauma to the palm area may also lead to the above symptoms, such as extrusion injuries to the palm, palm fracture, etc.; compression of the nerves innervating the middle part of the palm may also cause pain in the middle part of the palm, such as tendon sheath cysts leading to the compression of the median nerve, cervical spondylosis and so on. The symptoms of pain in the middle of the palm alone sometimes cannot determine the cause accurately, but also need to be combined with the characteristics of the medical history, other test results to make an accurate judgment, it is recommended to clarify the cause of the disease under the guidance of a doctor.