Immunoglobulins may be high in patients with dry syndrome, with predominantly elevated IgG, which is polyclonal. The presence of hyperglobulinemia is also not excluded. Dry syndrome is a diffuse connective tissue disease characterized by invasion of exocrine glands such as lacrimal and salivary glands, abnormal proliferation of B-lymphocytes, and infiltration of tissue lymphocytes. Clinically, it mainly manifests as dry keratoconjunctivitis and oral dryness, and can also involve internal organs. Patients with dry syndrome can be found to improve the relevant laboratory examination of immunoglobulin increase, and mainly IgG elevation, polyclonal, and a few patients can also appear macroglobulinemia. When the presence of hyperglobulinemia is suggested, it is necessary to promptly assess whether there is involvement of the kidneys, liver, nervous system, blood system, etc., and glucocorticosteroids, such as prednisone, can be administered for treatment if necessary. Dry syndrome requires regular review, if abnormalities are found, it is recommended to consult a doctor in time and follow the doctor’s instructions to standardize the diagnosis and treatment. Daily attention should be paid to avoid prolonged sun exposure, minimize exposure to chemical substances, etc., while maintaining balanced nutrition and avoiding spicy and stimulating foods.