For patients with hepatitis B with splenomegaly and nausea, targeted dietary modifications, medications, or surgical resection are needed. Hepatitis B patients can have gastrointestinal symptoms, hypersplenism and splenomegaly with the progress of the disease, and they should be treated with dietary adjustments as well as medication and surgery. 1. Diet: patients with hepatitis B should give up alcohol, if nausea occurs in eating, appropriate dietary protein, if the patient is seriously ill, to choose a low-protein diet, and to choose high-vitamin, easy to digest food, but need to eat appropriately, so as to avoid over-nutrition, triggering fatty liver. 2. Drugs: In drug treatment, generally take viral drug treatment (such as lamivudine, entecavir, tibivudine, etc.) and antifibrotic drug treatment (such as Anluohua Fibroblast Pill, Compound turtle shell soft liver tablet, etc.) as the main treatment. 3. Surgery: If hepatitis B patients have cirrhosis with hypersplenism, or even with large amount of bleeding from upper gastrointestinal tract, it is necessary to remove the enlarged spleen. If patients with hepatitis B have serious symptoms of splenomegaly and nausea, or the symptoms persist and do not get better, they should go to the hospital in time for treatment.