The pharmacological mechanism of ivabradine is to inhibit the cardiac sinus node pacing If current, thereby reducing cardiac autonomy and slowing down the heart rate.
Ivabradine belongs to the drugs that simply reduce the heart rate, can selectively inhibit the cardiac sinus node pacing current If current (sinus node diastolic depolarizing current), thus inhibiting the role of the sinus node pacing, reducing myocardial arrhythmia and slowing down the heart rate.
This drug has no effect on other conduction tissues such as atrioventricular node, Hirschsprung’s bundle, Purkinje fibers, etc., and thus does not affect atrioventricular conduction, ventricular repolarization, cardiac contraction and other processes. This drug is indicated for patients in sinus rhythm ≥ 75 beats/min with heart failure.
Note that it is contraindicated in patients with cardiogenic shock, acute myocardial infarction, severe hypotension and bradycardia (blood pressure <90/50 mmHg, heart rate <70 beats/min), severe hepatic insufficiency, morbid sinus node syndrome, sinus block, unstable or acute heart failure, patients with pacemaker-dependent conditions, atrioventricular block of the IIIrd degree, and allergy to this drug.
Adverse reactions such as bradycardia, flashing phenomenon, atrial fibrillation, skin rash may occur after taking this drug. Take care to use the drug under the supervision of a physician.