Long-term drinking and sudden weight loss may be due to nutritional deficiency, diabetes, hyperthyroidism, liver disease and other reasons. 1. Nutritional deficiencies: Long-term drinkers may reduce their intake of staple foods, and when this continues for a longer period of time, it may lead to nutritional deficiencies, which in turn leads to metabolic disorders and weight loss. 2. Diabetes mellitus: long-term alcohol consumption may lead to elevated blood glucose, and may also aggravate the burden on the liver, resulting in metabolic disorders, which may lead to weight loss. 3. Hyperthyroidism: For those who suffer from hyperthyroidism, the secretion of thyroid hormone will increase, and excessive thyroid hormone can also promote protein decomposition, and some patients will also have the symptom of emaciation. 4. Liver disease: Long-term alcohol consumption can cause damage to liver function, which may lead to cirrhosis, liver cancer and other liver diseases in serious cases, and may also lead to the phenomenon of sudden weight loss. The symptoms of long-term drinking and sudden weight loss, it is recommended to consult a doctor in a timely manner, combined with the relevant program examination, to clarify the specific causes of the disease, and then targeted treatment.