Long-term rational medication is needed after bypass surgery to maintain the surgical effect, which should be taken strictly in accordance with medical advice, and any discomfort should be consulted to the doctor in time, and should not be stopped or increased or decreased by oneself. 1, to prevent thrombosis drugs: anti-platelet aggregation drugs, such as aspirin, Bolivar, etc., can prevent thrombosis and prolong the life of the bridge vessels. Aspirin needs to be taken for life after surgery, but there is a certain amount of gastrointestinal irritation, which may cause symptoms such as gastrointestinal bleeding, and needs to be taken after meals. 2.Drugs to prevent the progress of atherosclerosis: Statins, such as simvastatin and atorvastatin, have the effects of lowering blood lipids, anti-inflammation, protecting vascular endothelial function, delaying the progress of atherosclerosis and stabilizing plaque. The good control of lipid level is the key to influence the long-term efficacy after bypass surgery and should be used for a long time. However, lipid-lowering drugs have certain liver damage, so blood lipid and liver function should be tested regularly, and fasting is required before blood sampling. 3, prevention and control of hypertension, reduce the burden of the heart drugs: (1) β-blockers: Bisoprolol, metoprolol, etc., the main role is to control the heart rate, reduce myocardial oxygen consumption, inhibit arrhythmias, lower blood pressure. (2) Angiotensin-converting enzyme inhibitors: Enalapril, perindopril, etc., mainly used to improve myocardial and vascular wall remodeling, slow down the process of atherosclerosis, improve the prognosis, especially in patients with combined diabetes, renal disease, hypertension, etc. to be taken for a long time. (3) Nitrates: nitroglycerin, long-acting isoleucine, etc., mainly improve angina symptoms by dilating coronary arteries, and also protect endothelial function. It is beneficial to keep the coronary artery open early after bypass surgery. D. Calcium antagonists: there are loxodil, heshinshang, etc., can prevent bridge vasospasm and improve myocardial ischemia caused by coronary spasm 4. Other drugs: including hypoglycemic drugs, digoxin, diuretics, etc., should be taken strictly according to medical advice, and patients with combined diabetes should strictly control blood sugar.