The main causes of knee pain in uremia dialysis are amyloidosis and renal bone disease. 1. Amyloidosis: with a history of long-term hemodialysis, it can manifest as carpal tunnel syndrome, persistent joint effusion, spondyloarthropathies, and cystic bone injury. Joint effusion mostly involves large joints bilaterally (e.g., shoulder, knee, wrist and hip), which leads to uremic dialysis knee pain. 2. Renal bone disease: due to uremia patients, toxin accumulation, calcium and phosphorus metabolism disorders and other further development, there will be metastatic calcification, resulting in renal bone disease, fracture or fibrous osteitis, and at this time dialysis will still have knee pain symptoms, so it can be manifested as uremia dialysis knee pain. Uremia dialysis knee pain should be further examined in the hospital and treated under the guidance of professional doctors.