Obesity-associated nephropathy is a disease that causes various endocrine metabolism disorders in the body due to obesity of patients, leading to kidney damage. Specifically, it needs to be analyzed from the etiology, clinical features and diagnosis. 1. Etiology: obesity causes hyperlipidemia, lipid deposition in the epithelial cells of renal tubules to form foam cells, which promotes the production of thylakoid matrix and participates in glomerulosclerosis. Obesity can cause insulin resistance and hyperleptinemia, high insulin can damage the vascular endothelium, leptin induces glomerular endothelial cell growth and fibrosis, aggravating glomerulosclerosis and damage; obesity can also lead to the activation of the RAS, thus leading to kidney injury. 2. Clinical features: insidious onset, no age onset characteristics, early micro-proteinuria, typically manifested as nephropathic proteinuria or non-nephropathic proteinuria, some patients can be combined with microscopic hematuria. Some patients may have microscopic hematuria. It may be accompanied by hypertension, hyperlipidemia, insulin resistance and hyperuricemia. 3. Diagnosis: Body mass index (BMI) ≥28kg/㎡, and exclude endocrine and pharmacological obesity. Proteinuria>0.3g/24h, mild microscopic hematuria, no history of episodes of carnal hematuria. Renal ultrasound volume increased, light microscopy simple glomerular hypertrophy, focal segmental glomerulosclerosis. As well as abnormal metabolic syndrome related indicators. Obesity can cause hypertension, diabetes mellitus, coronary heart disease, nephrotic syndrome and other diseases, so usually pay attention to participate in more sports, maintain a healthy diet, away from obesity and related diseases. Any discomfort, should be timely regular hospital consultation, active treatment, so as not to delay the condition.