What is the mechanism of elevated blood glucose in diabetes?

  Why does blood sugar rise?  In fact, the rise of blood sugar does not just rise, to this result will often go through a very complex physiological process.  First, let’s understand what is blood sugar. The sugar in the blood is blood sugar, and what we usually call blood sugar is generally glucose, which not only provides our body with the energy it needs on a daily basis, but also participates in the physiological processes such as the composition of the body’s tissues.  Second, where does blood sugar come from? Most of the sugars we take in come from food, which can be divided into polysaccharides (mainly starch), oligosaccharides (sucrose, lactose, etc.) and monosaccharides (the famous glucose, fructose, galactose, etc.). The larger polysaccharides and oligosaccharides cannot be taken up directly by the body and must be gradually broken down into monosaccharides with the participation of various digestive enzymes before they can be absorbed into the bloodstream in the upper part of the small intestine.  Where do glucose sugars go in the blood? After entering the blood, glucose is not only directly taken up and used by the tissues and organs of the body, but also has three other destinations: 1) to be taken up by the liver and muscles and then synthesized into glycogen for storage; 2) to be excreted from the urine through the kidneys when the blood glucose concentration is high; 3) to be converted into other sugars and non-sugar substances.  Fourth, the balance of blood sugar. Under normal circumstances, the blood glucose value is maintained in a specific range. As the glucose in the blood is continuously taken up and utilized, the blood glucose concentration gradually decreases, at which time the glycogen in the liver and muscles just mentioned will be mobilized to decompose again to produce glucose for use by the organism. If starvation lasts for a long time, the body will also convert some of the amino acids and lactic acid into sugar, so that a balanced state will be maintained.  Why does blood sugar rise abnormally?  In fact, the regulation of blood glucose homeostasis is very complex and is regulated by neurohumoral-endocrine mechanisms to maintain blood glucose values within a specific range, i.e. glucose homeostasis, and the key player in this process is insulin.  Unfortunately, for some reasons, it may lead to, for example, pancreatitis, viral infection, overload of pancreatic islets (such as insulin resistance), etc., resulting in a decrease in the function of insulin secretion by pancreatic islets and an absolute shortage of insulin, and blood glucose homeostasis will be broken and cannot be broken down and utilized in time, resulting in the accumulation of glucose in the blood and causing blood glucose to rise.  The above is the mechanism of blood glucose elevation, from which we can also find out the methods to control blood glucose, such as restricting diet to reduce sugar intake, exercising more to increase glucose consumption, and medication to promote insulin secretion or think of insulin supplementation, etc. In this way, we can control blood glucose to reach the standard and avoid complications.