Nephrocalcinoma and renal staggered tumor are two renal tumors with different tissue origins; the former is malignant while the latter is benign. There is no relevant clinical evidence that the two are transformed. Renal carcinoma is the most common primary renal malignant tumor originating from renal tubular epithelial cells, and the pathological types include clear cell carcinoma, smoky cell carcinoma, papillary cell carcinoma, and medullary carcinoma, most of which are clear cell carcinoma. Renal staggered tumor, also known as renal angiomyosarcoma smooth muscle lipoma, is a benign renal tumor composed of various components such as blood vessels, smooth muscle and fat, which can be divided into disseminated type and nodular sclerosis type. The former refers to the simple appearance of renal stenoma, while the latter is a hereditary disease, accounting for about 20~30% of all patients. In addition to kidney lesions, multiple organs such as skin, lungs and brain can also be involved. Kidney cancer and renal stenoma are two different kinds of kidney tumors, there is no clear correlation between them, and there is no evidence to show that renal stenoma will be transformed into kidney cancer, therefore, patients with renal stenoma don’t need to worry too much, and it is recommended to go to regular hospitals as soon as possible, and ask the professional doctors to evaluate the condition and then formulate a reasonable treatment plan.