Gastric mucosal thickening is a description of the results of gastroscopy and other tests, and whether it can be cured needs to be judged according to the cause of the disease. If the cause is Helicobacter pylori infection, inflammation stimulation, etc., the prognosis is good after regular treatment with oral medication, but if the cause is chronic atrophic gastritis with severe atypical hyperplasia or gastric cancer, the prognosis of gastric mucous membrane thickening is poorer. 1. Helicobacter pylori infection, chronic inflammatory stimulation can lead to thickening of gastric mucosa, and the prognosis is generally good after taking oral antibiotics, acid suppressants, bismuth, gastric mucosal protectants and other medications as prescribed by the doctor. 2. Chronic atrophic gastritis can also lead to thickening of gastric mucosa, some patients can be improved or reversed through regular treatment, but patients with severe atypical hyperplasia or those who have developed into gastric cancer have a poorer prognosis, but active treatment can effectively alleviate the symptoms, reduce the risk, and improve the quality of life of patients. After discovering the thickening of gastric mucosa, patients should consult the doctor in time and take targeted treatment after clarifying the cause of the disease, so as to avoid delaying the condition.