High total cholesterol and HDL can be improved by controlling high-fat food, and patients with multiple risk factors need to take oral statin therapy. High total cholesterol is harmful to human body and will promote the development of atherosclerosis, usually need to control the intake of high-fat food, reduce the intake of animal fats, fish seeds, egg yolks and other foods, and eat more vegetables; high HDL is beneficial to human body and should continue to maintain, do not need to take oral medication. Total cholesterol is high if combined with a variety of risk factors, such as early onset of cardiovascular disease family history, smoking, clear already occurred cardiovascular disease, belongs to the high-risk patients, need to take oral statin drug treatment, commonly used drugs are Rosuvastatin, LDL level <1.8mmol/L. Adverse reactions of Rosuvastatin include constipation, nausea, gastrointestinal discomfort, myalgia, malaise, rash, etc. It is contraindicated in patients who are allergic to the drug components, have elevated severe liver disease, have impaired severe renal function, are taking cyclosporine, and have myopathy. Patients with elevated blood lipids should be treated under the guidance of a physician with appropriate medication, but pay attention to the adverse effects of the drug.