Primary infertility without treatment is very difficult to get pregnant, after treatment may be able to get pregnant, but not absolutely. Women who have sex with their spouses for one year and more, without contraception women have not been able to get pregnant successfully naturally, for primary infertility, without targeted to the treatment, it is very difficult to get pregnant. The causes of primary infertility are many, such as semen abnormalities, immune factors, ovulation disorders, fallopian tube factors, uterine factors, cervical factors, etc., to understand the cause of the disease and then targeted treatment, the treatment may be able to get pregnant naturally, for example, there are patients with tubal blockage, through the treatment of the fallopian tubes, the woman will be more likely to get pregnant after coitus. Primary infertility has more causes, whether it is difficult to get pregnant, to go to the hospital through the examination to determine.