Knee pain may be related to medial and lateral collateral ligament injuries, rheumatoid arthritis, osteophytes, etc., which need to be treated with medication for the cause, and there is no specific medicine. 1. For pain caused by injury to the medial and lateral collateral ligaments, non-steroidal anti-inflammatory drugs such as ibuprofen can be taken orally as prescribed by the doctor, which can alleviate the pain symptoms. 2. For pain caused by rheumatoid arthritis, analgesics such as ibuprofen, glucocorticosteroids such as prednisone, and antirheumatic drugs such as leflunomide can be used as prescribed by the doctor. 3. For the pain caused by osteomalacia, oral non-steroidal anti-inflammatory drugs such as celecoxib can reduce the inflammatory response and relieve the pain as prescribed by the doctor. It is recommended that people with knee pain consult a doctor in time to clarify the cause of the disease and standardize the treatment under the guidance of the doctor.