Long-term use of valsartan amlodipine may result in drug resistance and reduced effectiveness for people with high blood pressure. Long-term use of valsartan amlodipine will not only make the efficacy of valsartan amlodipine greatly reduced, but also lead to the development of drug resistance to valsartan amlodipine in users. However, valsartan amlodipine is recommended for patients with grade 2 or higher hypertension or those with poorly controlled hypertension and can be taken on a long-term basis. Valsartan amlodipine is used in the treatment of essential hypertension in patients whose blood pressure is not adequately controlled by monotherapy. The use of this drug is prohibited for those who are allergic to the components of the drug, pregnant and lactating women, severe liver and kidney insufficiency. Valsartan amlodipine may cause headache, edema, fatigue, insomnia, nausea, abdominal pain, redness of the face, palpitations (rapid heartbeat, often accompanied by panic) and dizziness; also see itching, rash, dyspnea, coughing, sweating, muscle cramps. Overdose can lead to persistent low blood pressure and other adverse reactions. Drugs are to be used under the guidance of a doctor, to avoid self-medication.