Subcutaneous tissue sclerosis is the clinical manifestation caused by simple varicose veins of lower extremities, which is generally not serious, mainly manifested by sinuous expansion and tortuosity of superficial veins of lower extremities, if the disease continues to progress, to the late stage, especially when the traffic vein valves are destroyed, mild swelling and nutritional changes of skin in the foot and boot area may occur, including skin atrophy, desquamation, pruritus, hyperpigmentation, skin and subcutaneous tissue sclerosis, and even eczema and ulcers formation. Differential diagnosis of subcutaneous tissue sclerosis: 1. Subcutaneous fatty grains: Fatty grains are small white bumps, about the size of a pinhead, that grow on the skin and look like a small white sesame seed, usually on the face, especially around the eyes in women. They are usually found on the face, especially around the eyes of women. They are caused by tiny wounds on the skin, and as the skin repairs itself, a small white cyst is created. It may also be due to the sebum being covered by keratin and not draining properly to the epidermis, thus accumulating with the white particles formed in the skin. Subcutaneous mass nodules ranging from fingertips to pigeons’ eggs: The clinical manifestations of lymphatic larvae are inflammatory mass nodules ranging from fingertips to pigeons’ eggs located under the skin of the trunk or lower extremities, with one to two nodules, and edema and itching in the affected area. 3. Subcutaneous deposition of corn-like nodules: oxalate crystal arthropathy The deposition of oxalate crystals in the joints can lead to acute and chronic lesions in a variety of joints, most often involving the knee and hand joints, while lesions in other joints, such as the wrist, ankle, foot joints and tendon sheaths and joint capsules, have also been reported repeatedly. Patients treated with hemodialysis or peritoneal dialysis for renal failure can also develop oxalate deposits in the intervertebral discs, the latter often leading to destruction and degeneration of the discs. Deposition of oxalate crystals in other tissues can also lead to local necrosis, cardiomyopathy or heart block due to insufficient blood supply, corn-like nodules due to subcutaneous deposition, peripheral neuropathy, and aplastic anemia. 4, subcutaneous nodules: subcutaneous nodules are hard, round or oval, painless nodules. The diameter is 0.2 to 10 cm in size. They are often located in areas subject to more friction, such as the elbow extension, Achilles tendon, scalp, sciatic nodes, or around joints. Rare sites include the ear and nasal bridge. Subcutaneous nodules rarely cause symptoms and may occasionally rupture or become infected. The typical subcutaneous nodule is slow growing and may persist or disappear in remission. The presence of subcutaneous nodules is closely associated with high titers of serum rheumatoid factor, severe joint destruction, and active rheumatoid lesions.