Subcutaneous tissue sclerosis is a clinical manifestation caused by simple varicose veins of the lower limbs, generally not serious, mainly manifested as the lower limbs of the superficial veins meandering expansion of tortuous, such as the course of the disease continues to progress to the late stage, especially when the destruction of traffic vein valves, there can be a mild swelling and boot area skin trophic changes, including skin atrophy, desquamation, itching, hyperpigmentation, skin and subcutaneous tissue sclerosis, and even eczema and ulcer Formation. (I) Pathogenesis Congenital venous wall weakness and poor venous valve structure are the main causes of the disease. Heavy physical labor, prolonged standing and increased abdominal pressure caused by various reasons can make the valves withstand excessive venous pressure, and in the case of poor valve structure, it can lead to incomplete valve closure and produce blood regurgitation. Due to the thin muscular layer of the superficial vein wall and the lack of connective tissue around it, blood reflux can cause the veins to grow and thicken, resulting in varicose veins. Due to the increase of venous pressure in the lower limbs, a large number of capillary hyperplasia and increased permeability can occur in the boot area, resulting in hyperpigmentation and liposclerosis. Due to the accumulation of a large amount of fibrinogen, the exchange between capillaries and surrounding tissues is impeded, which can lead to trophic changes in the skin and subcutaneous tissues. (The main hemodynamic changes of varicose veins occur during the contraction of calf muscles. Due to the destruction of the venous valves that protect the unidirectional flow of blood, the blood from the deep veins flows backward into the superficial venous system. The wall of the vein itself is weak, thus leading to the growth and thickening of the vein and the appearance of varicose veins. Barnandl and Browse’s study showed that in the hyperpigmented and liposclerotic areas of varicose veins of the lower extremities, there is a large amount of capillary proliferation. And due to the increase in the pore size between the endothelial cells of the capillaries, it leads to a large leakage of osmotically active particles, especially fibrinogen, and at this time the fibrin solubility of the veins decreases, so a large amount of fibrin accumulates as a sheath around the capillaries, which prevents the exchange of oxygen and nutrients between the capillaries and their surrounding normal tissues, and so trophic changes appear in the skin and subcutaneous tissues.