Whether a whitening cream should be used in the daytime or at night depends on the ingredients it contains. If it contains photosensitive ingredients, using it during daytime may cause pigmentation, which will have some effect on the effect of spot removal, so it is recommended to use it at night; if it does not contain photosensitive ingredients, it can be used during daytime or nighttime. From the choice of human skin cell repair time, it is better to apply whitening and spot removal cream at night. This is because the cell division of the skin will proceed to its peak in the evening, especially from 10:00 pm to 2:00 pm at night is the most active time of division. Therefore, the evening is the golden time for the skin to repair itself, and it is also the best time for skin whitening maintenance. If you choose to use whitening spot cream at night, you should clean your face well before applying it to prevent surface stains and oil from entering the pores, leading to clogged hair follicles and acne, etc. After cleaning the skin of your face, you should carry out a secondary cleaning and softening of the facial cuticle with moisturizing water. Apply moisturizing lotion to nourish the face skin after shooting water. Finally, you can take the whitening blemish cream and put it on the palm of your hand, rub it with both hands until it dissolves, then rub the dissolved blemish cream evenly on the spots on your face, when you rub it, you can push your face in a circular way until your face completely absorbs the blemish cream. It is recommended to choose regular products when purchasing whitening spot removal creams. Before using it, you can observe whether there is any allergic reaction by applying a small amount locally. If an allergic reaction occurs, you must not continue to use the relevant product and seek medical treatment if necessary.