The difference between hiccuplau and azithromycin mainly includes the following points: first, the type of antimicrobial agent: the two belong to different types of antimicrobial drugs, the former belongs to the second generation of cephalosporins, the latter belongs to macrolides; second, the mechanism of action: the former mainly inhibits the cell wall synthesis of bacteria to achieve the purpose of sterilization, while the latter mainly binds to the ribosome of bacteria, inhibiting protein synthesis and The latter mainly binds to the ribosome of bacteria, inhibiting protein synthesis and acting as a bacteriostatic agent. So the former is a bactericidal agent, the latter is a bacteriostatic agent; third, antibacterial spectrum coverage: the former for most of the gram-positive cocci and negative bacilli have strong bactericidal activity, while the latter for gram-positive cocci have antibacterial activity, but for gram-negative bacilli in most cases ineffective, only for Haemophilus influenzae is more sensitive; fourth, against atypical pathogens: cephalosporins for atypical pathogens, such as Mycoplasma, Chlamydia, etc., have no obvious effect and can be basically said to be ineffective. Azithromycin has stronger activity against mycoplasma, chlamydia, legionella, non-tuberculous mycobacteria, etc.; fifth, adverse reactions: the main adverse reaction of the former is gastrointestinal symptoms, while the main adverse reaction of the latter is liver damage.