Brucella etiology: The etiology of this disease is Brucella, a Gram-negative bacterium. It can be caused by direct contact with the secretions and excretions of infected animals, by drinking unpasteurized milk, goat’s milk, or by eating dairy products containing live Brucella, or by eating undercooked meat. Human-to-human transmission is rare. The disease is more prevalent in rural areas and is an occupational disease of meat processors, veterinarians, farmers and herders. Symptoms of Brucellosis: (1) Fever. The most common symptom in the acute phase. (2) Joint and muscle pain. (3) Reproductive symptoms. Testicular inflammation and epididymitis may occur in male patients. Female patients may have irregular menstruation, amenorrhea, premature birth, miscarriage, stillbirth, etc. (4) Neurological symptoms. Neuralgia. (5) Lymph nodes and liver and spleen are large. (6) Complications are rare, but can infect the heart, brain (the aforementioned 17-year-old boy is the brain infection) and meninges, etc. Diagnosis of Brucellosis: 1. History of residence in endemic areas, history of contact with diseased animals and their discharges before the disease, history of handling aborted animals or history of drinking unsterilized milk; 2. Typical clinical signs and symptoms; 3. Blood culture and bone marrow culture. The rate of positive blood culture in the acute stage can reach 80%. Treatment of brucellosis: WHO (World Health Organization) recommends the combination of doxycycline and rifampin for 6 weeks. In addition quinolones, such as moxifloxacin has a good intracellular penetration, the effect is remarkable, we are using moxifloxacin to cure the above three patients. Compound sulfamethoxazole can penetrate intracellularly and reduce fever faster in acute patients. Patients with brucellosis meningitis can apply ceftriaxone in combination with rifampin. Prevention of brucellosis 1. Management of the source of infection: Strengthen the management of sick animals and find that the affected animals should be isolated in special pastures. Aborted fetal cover should be buried deeply with quicklime. Diseased people should be isolated in time. The patient’s excrement and pollutants should be disinfected; 2. Cut off the transmission route: dairy, meat and fur in the infected area should be strictly disinfected and sterilized before being shipped out. Protect water sources; 3. Protect susceptible people and animals: All people who are likely to be infected with the disease should be vaccinated.