The fastest way to eliminate pericardial effusion is pericardiocentesis and aspiration, but it is only applicable in some cases, and the exact treatment should be determined by the patient’s condition. The treatment plan for pericardial effusion depends on the amount of fluid, the speed of fluid production, and the etiology of fluid production, and its treatment is categorized into etiological treatment and symptomatic treatment. 1. Symptomatic treatment includes anti-inflammation, regulation of serum protein levels, and pericardiocentesis. Pericardiocentesis is suitable for those who have cardiac tamponade and drug treatment is ineffective. It is also the fastest way to eliminate pericardial effusion, but it cannot prevent recurrence. 2. Causative treatment is to treat the cause of the disease. For example, if pericardial effusion is caused by tuberculosis, anti-tuberculosis treatment can effectively eliminate pericardial effusion and prevent its recurrence. It is recommended to choose the appropriate treatment according to the condition after diagnosis by a doctor.