The reference range of 24-hour urine protein quantification is 0-0.15g, if the urine protein quantification increases, it can be seen in kidney disease, heart disease, liver disease, thyroid function disease, etc. When the 24-hour urine protein quantification is more than 3.5g, it is called massive proteinuria, which can be clinically seen in nephrotic syndrome, diabetic nephropathy, tumor-associated nephropathy, etc. It is recommended to further check the liver function, ion renal function, It is recommended to further investigate liver function, ionized renal function, urological ultrasound, systemic tumor markers, and so on. If combined with hyperlipidemia, edema, hypoalbuminemia, considered as nephrotic syndrome, need to further perform renal puncture biopsy to clarify the pathological type, if necessary, the use of immunosuppressive therapy. If the patient is hypertensive or diabetes mellitus for many years caused proteinuria, it is recommended to actively treat the primary disease, antihypertensive, hypoglycemic and other treatments, the most commonly used drugs are ACEI or ARB drugs.