Systemic muscle pain is most commonly associated with inflammatory pain caused by infection, such as fever, and vascular irritation caused by the accumulation of acidic metabolites in the body due to prolonged anaerobic activity. If the patient has a combination of fever and other symptoms and the test results indicate elevated inflammatory parameters, the patient may be given non-steroidal anti-inflammatory drugs to reduce symptoms and, if necessary, antiviral anti-inflammatory therapy. If the concentration of acidic metabolites in the blood test is elevated, patients are advised to drink more water to promote the excretion of acidic metabolites, take rest recently, minimize strenuous exercise, and apply local heat therapy and massage to the painful area to promote blood circulation and help relieve symptoms.