The normal value of spleen thickness is 3~4cm, and spleen thickness of 5.3cm is in a thicker state, this phenomenon may be physiological factors or pathological factors, such as viral hepatitis, chronic hepatitis and so on, which can cause the symptoms of spleen thickness. It can be treated by changing dietary habits, medication and surgery. 1. Physiological factors: under normal circumstances, hematopoiesis is carried out by bone marrow, the reduction of compensatory capacity of blood cells and bone marrow will lead to extramedullary hematopoiesis, and the spleen will be enlarged to a certain extent due to the hyperplasia of hematopoiesis. In daily life, we should pay attention to the light diet, keep a happy mood, and go to the hospital regularly for review. 2. Viral hepatitis: If caused by viral hepatitis, antiviral drugs such as dalatasvir and sofosbuvir should be taken under doctor’s guidance. At the same time, assess whether it is accompanied by splenic hyperfunction, if necessary, the spleen needs to be removed. 3. Chronic hepatitis: splenomegaly is commonly caused by chronic hepatitis, which can result in splenomegaly and affect many indicators of the human body. The treatment of splenomegaly is based on surgical resection, and at the same time, it is necessary to effectively control primary hepatitis and liver diseases to avoid aggravation of the symptoms. In addition, hepatitis B, cirrhosis and spleen tumors can also lead to symptoms of splenomegaly. After ruling out physiological factors, one should consult a doctor in time to ask him to clarify the cause of the disease and treat the symptoms for early recovery.