Tumors of the lymph nodes are divided into primary lymph node tumors, known as lymphoma, and metastatic lymph node tumors, known as lymphatic metastases. The treatment of lymphoma is a combination of chemotherapy, mainly radiotherapy and chemotherapy. Lymphoma is divided into Hodgkin’s lymphoma and non-Hodgkin’s lymphoma. The main chemotherapy regimens for Hodgkin’s lymphoma are MOPP, ABVD, and other regimens. Radiotherapy for this category of patients requires an expanded field of irradiation because the lymph nodes tend to have jumpy lesions. The chemotherapy regimens for non-Hodgkin’s lymphoma include CHOP, CVP, etc. Since most of the non-Hodgkin’s lymphoma is B-cell in nature, for this group of patients, CD20 expression testing can be performed on lymph node sections, and if the expression is high, the targeted drug rituximab, also known as melphalan, can be used in combination for better results. With continuous advances in treatment, lymphoma has become one of the potentially curable tumors. There are also metastatic tumors in the lymph nodes. This group of patients requires treatment of the primary disease and local radiation therapy for the metastatic lymph nodes.