At present, the general safety of topical anesthetics are relatively high, for the human body, will not produce serious effects, because the metabolic time of anesthetics are relatively short, and will not remain in the body for a long time, but if there are significant individual differences, in the external use of anesthetics may indeed appear irritating symptoms, as follows: 1, local skin allergic reactions: such as the surface of the skin appeared red, swollen, itchy, painful symptoms. 2, anaphylaxis: is the most serious complication, according to the individual’s physique, when necessary, need to be actively resuscitated, through active anti-shock treatment, can make effective improvement of anaphylaxis.