Topical antibiotics will encounter more side effects, the clinical has not recommended for routine use, long-term topical antibiotics often have the following hazards: First, drug-resistant reactions, if long-term use of antibiotics for infected wound change treatment, the patient’s wound will soon occur drug-resistant reactions, that is, the effect of antibiotics significantly weakened, can change the normal bacterial environment within the wound, and is not conducive to faster wound healing. Second, drug allergic reactions, most antibiotics require skin testing to detect whether the patient is allergic. And in the case of topical antibiotics, there is no skin test detection, antibiotics can be absorbed into the blood through the mucous membrane of the local wound, causing the body to have an allergic reaction, such as itching, redness, swelling, pain of the skin, and even anaphylactic shock if the symptoms are severe.