The relationship between obesity and urolithiasis

In recent years, it has been noted that the incidence of urolithiasis is significantly higher among obese and overweight people in Western countries. Data from the United States show that the number of obese and overweight people with urolithiasis is 1.8 times that of other people. Obese people tend to have high uric acid urine, gouty body, high calcium urine, uric acid stones, and obese women are more likely to suffer from urolithiasis than men. The pathophysiological mechanisms that lead to urolithiasis may include; urinary injuries caused by sugars, the intake of carbohydrates, the resistance of the plate island to the bone Yi Dai Man and the “small solution to the problem”), the whole photo and the high Cheng Cheng living in the development of a group plus, the love of electricity to get the quality of quality and delivery of goods some unknown other abnormalities. Regular intake of refined carbohydrates promotes urolithiasis. Obese patients with urolithiasis have low uridine and low urine pH. Obese patients are also often comorbid with hypertension, which tends to form calcium oxalate stones. It has been found that the risk of stone formation is more than four times higher in hypertensive patients than in normal people. Hypercalciuria, hyperoxaluria and hyperuricosuria are all more common in patients with high blood pressure than in those with normal blood pressure, which may be related to their dietary habits, such as an increased intake of purines through red meats. Irregular life, obesity, and poor dietary habits promote stone formation. About of the patients with recurrent stones have more than 3 recurrences. To prevent recurrence of stones, 15% of patients with urolithiasis require metabolic evaluation. Mean 24-hour urine pH decreases with body weight in patients with urolithiasis. In women, urinary oxalate excretion rate was positively correlated with BMI. The urinary oxalate excretion rate was 39% higher in obese women than in normal women. In overweight women, increased urinary oxalate was associated with excessive intake of chocolate (rich in oxalic acid). Obese patients with stones have high urinary osmolality and low pH, and high urinary uric acid concentrations. Limiting animal protein and salt in food has an important role in reducing the risk of recurrence of calcium oxalate stones in men with idiopathic hypercalciuria. A low-fat or weight-loss diet reduces the risk of urolithiasis, and weight loss and drinking plenty of water are the first line of treatment for overweight and obese patients with urolithiasis.