Self-treatment of lower limb atherosclerosis occlusion includes exercise therapy and smoking cessation. If diagnosed, medication and surgery are recommended under the guidance of a doctor. 1. If the patient’s condition is mild and stable, self-treatment can be carried out, such as exercise therapy, and smoking cessation should be carried out at the same time. (1) Exercise therapy: For patients with intermittent claudication, it is recommended to exercise by walking to promote the growth of new blood vessels. (2) Smoking cessation: to reduce the stimulation of cigarettes on the endothelium and improve the patency of the arteries in the extremities. 2. It is recommended to carry out standardized drug treatment and surgical treatment under the guidance of doctors. (1) Drug therapy: commonly used drugs include atorvastatin, which lowers cholesterol and prevents atherosclerotic plaque formation; antiplatelet drugs such as aspirin, which improves the patient’s hypercoagulable state; and vasodilator drugs such as cilostazol, which promotes the establishment of collateral circulation. (2) Surgical treatments: for example, peripheral artery bypass grafting, which allows blood to reach distant diseased vessels; percutaneous lower limb artery intervention, which opens narrowed or occluded blood vessels through manipulation of the vascular lumen. Exercise therapy and smoking cessation can only reduce the risk factors for the disease, not cure it. If the diagnosis of atherosclerosis occlusion of the lower limbs is confirmed, it is recommended to actively consult a doctor and standardize the treatment under the guidance of the doctor.