HPV vaccination is generally not recommended for women after the age of 45 because they are older and produce few or no antibodies, so the effect after vaccination is not good. There is no uniform age rule for HPV vaccination in our country, and it will not be prohibited if you want to be vaccinated at the age of 45, but the effect of vaccination after the age of 45 is not good, so it is not recommended from the medical point of view. The World Health Organization recommends that the age for HPV vaccination is 9-45 years old, and the younger the age, the more effective the vaccination. For example, in the United States, the recommended age for HPV vaccination is 9-26 years old, while men and women over 26 years old are not recommended to be vaccinated.