Pegabine, generically known as polyethylene glycol interferon alpha-2b injection, the first side effect lasts for about 1 to 2 weeks, the exact duration of which is dependent on the patient’s individual constitution. Polyethylene glycol interferon alpha-2b injection is used to treat chronic hepatitis B or chronic hepatitis C. Early in treatment, it is likely to cause symptoms such as fever, nausea, headache, and fatigue, and may even cause excessive diarrhea and abdominal pain, as well as dizziness, anorexia, and anxiety. These side effects usually last for 1 to 2 weeks and resolve. If a patient experiences allergic symptoms with PEGylated Interferon alpha-2b Injection, he or she needs to be careful to avoid injecting this medication. In addition, the application of polyethylene glycol interferon alpha-2b injection carries certain risks and patients need to be guided by a specialist.